448. PREDICTORS OF RECURRENT LARYNGEAL NERVE PALSY RECOVERY FOLLOWING ESOPHAGECTOMY

Abstract Background Recurrent laryngeal nerve (RLN) palsy is a serious complication of esophagectomy that significantly impacts patients’ quality life. This condition can be permanent or temporary, and identifying the factors associated with recovery guide treatment options manage patient expectations. We aimed to investigate predictors from RLN after esophagectomy. Methods selected patients who underwent between 2003 2022, had minimum survival follow-up 6 months, experienced right, left, bilateral prospectively managed database. Recovery was defined as restoration vocal fold mobility within irrespective dysphonia symptoms while injury persistent cord six months. Univariate multivariable logistic regression analyses were used identify associations variables likelihood recovery. Results The overall rate 14.5%. Ninety-five included. mean age at operation 64.4 years. Fifty-two (54.7%) recovered palsy. Sixty-four (67.4%) minimally-invasive video-assisted thoracoscopic On analysis, neoadjuvant therapy (OR = 0.250, P 0.012), augmentation 0.283, 0.009), reconstruction via retrosternal route 0.326, 0.036) right chest 0.088, 0.046) reference orthotopic route, less likely recover Conclusion Neoadjuvant therapy, esophageal significant